Early T-cell Precursor Acute Lymphoblastic Leukemia- A Neoplasm with Dual Lineage Phenotype- Case Study of Two Patients
Published: 2021-06-07
Page: 93-99
Issue: 2021 - Volume 4 [Issue 2]
. Surabhi
Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
A. Singh
*
Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
J. Singh Nigam
Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
*Author to whom correspondence should be addressed.
Abstract
Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is a subtype of T-ALL/LBL which is derived from thymic cells at the early T-cell precursor (ETP) differentiation stage that have the potential to differentiate into multiple lineages, including lymphoid and myeloid. ETP-ALL accounts for 15% of childhood T-ALL and 10-30% of adult T-ALL. It has characteristic immunophenotypic expression of CD7, a lack of CD1a and CD8, weak expression of CD5 (with <75% positive blasts), and positive expression of one or more stem cell or myeloid markers including CD117, HLADR, CD13, CD33, CD11b or CD65. We here in report two cases of ETP-ALL with brief review of literature.
Keywords: ETP-ALL, T-ALL, CD1a, CD8